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VOLUME 3 , ISSUE 1 ( January-April, 2024 ) > List of Articles


The Myths and Facts about Corrected Calcium Levels

Pradeep M Venkategowda, Varun M Nagaraja

Citation Information : Venkategowda PM, Nagaraja VM. The Myths and Facts about Corrected Calcium Levels. 2024; 3 (1):54-55.

DOI: 10.5005/jp-journals-10089-0103

License: CC BY-NC 4.0

Published Online: 30-04-2024

Copyright Statement:  Copyright © 2024; The Author(s).


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  1. Peacock M. Calcium metabolism in health and disease. Clin J Am Soc Nephrol 2010;5(Suppl 1):S23–S30. DOI: 10.2215/CJN.05910809
  2. Boink AB, Buckley BM, Christiansen TF, et al. IFCC recommendation on sampling, transport and storage for the determination of the concentration of ionized calcium in whole blood, plasma and serum. J Automat Chem 1991;13(5):235–239. DOI: 10.1155/S1463924691000391
  3. Peoples JB. The role of pH in altering serum ionized calcium concentration. Surgery 1988;104(2):370–374.
  4. Aberegg SK. Ionized calcium in the ICU: should it be measured and corrected? Chest 2016;149(3):846–855. DOI: 10.1016/j.chest.2015.12.001
  5. Herrmann FR, Safran C, Levkoff SE, et al. Serum albumin level on admission as a predictor of death, length of stay, and readmission. Arch Intern Med 1992;152(1):125–130. DOI: 10.1001/archinte.1992.00400130135017
  6. Payne RB, Little AJ, Williams RB JR. Interpretation of Serum Calcium in Patients with Abnormal Serum Proteins. Br Med J 1973;4(5893):643–646. DOI: 10.1136/bmj.4.5893.643
  7. Steen O, Clase C, Don-Wauchope A. Corrected calcium formula in routine clinical use does not accurately reflect ionized calcium in hospital patients. Can J Gen Int Med 2016;11(3):14–21. DOI: 10.22374/cjgim.v11i3.150
  8. Ridefelt P, Helmersson-Karlqvist J. Albumin adjustment of total calcium does not improve the estimation of calcium status. Scand J Clin Lab Invest 2017;77(6):442–447. DOI: 10.1080/00365513.2017.1336568
  9. Smith JD, Wilson S, Schneider HG. Misclassification of calcium status based on albumin-adjusted calcium: studies in a tertiary hospital setting. Clin Chem 2018;64(12):1713–1722. DOI: 10.1373/clinchem.2018.291377
  10. Lian IA, Åsberg A. Should total calcium be adjusted for albumin? A retrospective observational study of laboratory data from central Norway. BMJ Open 2018;8(4):e017703. DOI: 10.1136/bmjopen-2017-017703
  11. Bowers GN Jr, Brassard C, Sena SF. Measurement of ionized calcium in serum with ion-selective electrodes: a mature technology that can meet the daily service needs. Clin Chem 1986;32(8)1437–1447. DOI: 10.1093/CLINCHEM/32.8.1437
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