Journal of Acute Care

Register      Login

VOLUME 3 , ISSUE 1 ( January-April, 2024 ) > List of Articles


Measurement of Pancreatic Stone Protein for Diagnosis of Sepsis in ICU Compared with C-reactive Protein and Procalcitonin: A Systematic Review

Enrico J Hartono, Septian A Permana, Vincent Kurniawan P Pratama

Keywords : C-reactive protein, Diagnosis, Intensive care, Pancreatic stone protein, Procalcitonin, Sepsis

Citation Information : Hartono EJ, Permana SA, Pratama VK. Measurement of Pancreatic Stone Protein for Diagnosis of Sepsis in ICU Compared with C-reactive Protein and Procalcitonin: A Systematic Review. 2024; 3 (1):18-22.

DOI: 10.5005/jp-journals-10089-0080

License: CC BY-NC 4.0

Published Online: 30-04-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Background: Sepsis remains a significant challenge in the intensive care unit (ICU), with prompt diagnosis and management being critical to improve patient outcomes. Biomarkers have emerged as valuable tools in identifying and predicting sepsis outcomes, with procalcitonin (PCT), pancreatic stone protein (PSP), and C-reactive protein (CRP) being three promising candidates. This systematic review is aimed to analyze and contrast the diagnostic accuracy of PCT, PSP, and CRP for sepsis in the ICU. Materials and methods: Literature was reviewed to examine the different diagnostic performances of the three biomarkers. The PubMed Central, PubMed, ScienceDirect, OxfordAcademic, SpringerLink, and Cochrane Database were searched in July 2023. The data regarding the area under curve–receiver operating characteristics (AUC–ROC) of the biomarkers were extracted. The Newcastle–Ottawa Quality Assessment Scale for Cohort Studies was used for evaluating included studies. Results: Three studies (n = 858) that examined the three biomarkers in adult patients admitted to the ICU were included. The biomarker PSP, along with the other two compared biomarkers, performs well and is proven reliable in diagnosing sepsis in adult patients hospitalized in the ICU. Conclusion: PSP, along with PCT and CRP, has shown reliability as a marker in diagnosing sepsis. This systemic review only emphasizes the accuracy of the three biomarkers in question.

PDF Share
  1. Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 2016;315(8):801–810. DOI: 10.1001/jama.2016.0287
  2. Hotchkiss RS, Moldawer LL, Opal SM, et al. Sepsis and septic shock. Nat Rev Dis Primer 2016;2(1):16045. DOI: 10.1038/nrdp.2016.45
  3. Dugani S, Veillard J, Kissoon N. Reducing the global burden of sepsis. CMAJ 2017;189(1):E2–E3. DOI: 10.1503/cmaj.160798
  4. Goodwin AJ, Ford DW. Readmissions among sepsis survivors: risk factors and prevention. Clin Pulm Med 2018;25(3):79–83. DOI: 10.1097/CPM.0000000000000254
  5. Lopes D, Chumbinho B, Bandovas JP, et al. Pancreatic stone protein as a biomarker of sepsis. Crit Care 2022;26(1):100. DOI: 10.1186/s13054-022-03953-x
  6. Pierrakos C, Velissaris D, Bisdorff M, et al. Biomarkers of sepsis: time for a reappraisal. Crit Care 2020;24(1):287. DOI: 10.1186/s13054-020-02993-5
  7. Vijayan AL, Vanimaya, Ravindran S, et al. Procalcitonin: a promising diagnostic marker for sepsis and antibiotic therapy. J Intensive Care 2017;5(1):51. DOI: 10.1186/s40560-017-0246-8
  8. Keel M, Härter L, Reding T, et al. Pancreatic stone protein is highly increased during posttraumatic sepsis and activates neutrophil granulocytes. Crit Care Med 2009;37(5):1642–1648. DOI: 10.1097/CCM.0b013e31819da7d6
  9. Que YA, Delodder F, Guessous I, et al. Pancreatic stone protein as an early biomarker predicting mortality in a prospective cohort of patients with sepsis requiring ICU management. Crit Care 2012;16(4):R114. DOI: 10.1186/cc11406
  10. Pugin J, Daix T, Pagani JL, et al. Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study. Crit Care 2021;25(1):151. DOI: 10.1186/s13054-021-03576-8
  11. Putallaz L, van den Bogaard P, Laub P, et al. Nanofluidics drives point-of-care technology for on the spot protein marker analysis with rapid actionable results. J Nanomed Nanotechnol 2019;10(5). DOI: 10.35248/2157-7439.19.10.536
  12. Nahm FS. Receiver operating characteristic curve: overview and practical use for clinicians. Korean J Anesthesiol 2022;75(1):25–36. DOI: 10.4097/kja.21209
  13. Hajian-Tilaki K. Receiver operating characteristic (ROC) curve analysis for medical diagnostic test evaluation. Caspian J Intern Med 2013;4(2):627–635. PMID: 24009950.
  14. Parlato M, Philippart F, Rouquette A, et al. Circulating biomarkers may be unable to detect infection at the early phase of sepsis in ICU patients: the CAPTAIN prospective multicenter cohort study. Intensive Care Med 2018;44(7):1061–1070. DOI: 10.1007/s00134-018-5228-3
  15. Oliveira CF, Botoni FA, Oliveira CR, et al. Procalcitonin versus C-reactive protein for guiding antibiotic therapy in sepsis: a randomized trial. Crit Care Med 2013;41(10):2336–2343. DOI: 10.1097/CCM.0b013e31828e969f
  16. Tan M, Lu Y, Jiang H, et al. The diagnostic accuracy of procalcitonin and C-reactive protein for sepsis: a systematic review and meta-analysis. J Cell Biochem 2019;120(4):5852–5859. DOI: 10.1002/jcb.27870
  17. Loots FJ, Smits M, Jenniskens K, et al. Added diagnostic value of biomarkers in patients with suspected sepsis: a prospective cohort study in out-of-hours primary care. J Appl Lab Med 2022;7(5):1088–1097. DOI: 10.1093/jalm/jfac031
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.