Measurement of Pancreatic Stone Protein for Diagnosis of Sepsis in ICU Compared with C-reactive Protein and Procalcitonin: A Systematic Review
Enrico J Hartono, Septian A Permana, Vincent Kurniawan P Pratama
Keywords :
C-reactive protein, Diagnosis, Intensive care, Pancreatic stone protein, Procalcitonin, Sepsis
Citation Information :
Hartono EJ, Permana SA, Pratama VK. Measurement of Pancreatic Stone Protein for Diagnosis of Sepsis in ICU Compared with C-reactive Protein and Procalcitonin: A Systematic Review. 2024; 3 (1):18-22.
Background: Sepsis remains a significant challenge in the intensive care unit (ICU), with prompt diagnosis and management being critical to improve patient outcomes. Biomarkers have emerged as valuable tools in identifying and predicting sepsis outcomes, with procalcitonin (PCT), pancreatic stone protein (PSP), and C-reactive protein (CRP) being three promising candidates. This systematic review is aimed to analyze and contrast the diagnostic accuracy of PCT, PSP, and CRP for sepsis in the ICU.
Materials and methods: Literature was reviewed to examine the different diagnostic performances of the three biomarkers. The PubMed Central, PubMed, ScienceDirect, OxfordAcademic, SpringerLink, and Cochrane Database were searched in July 2023. The data regarding the area under curve–receiver operating characteristics (AUC–ROC) of the biomarkers were extracted. The Newcastle–Ottawa Quality Assessment Scale for Cohort Studies was used for evaluating included studies.
Results: Three studies (n = 858) that examined the three biomarkers in adult patients admitted to the ICU were included. The biomarker PSP, along with the other two compared biomarkers, performs well and is proven reliable in diagnosing sepsis in adult patients hospitalized in the ICU.
Conclusion: PSP, along with PCT and CRP, has shown reliability as a marker in diagnosing sepsis. This systemic review only emphasizes the accuracy of the three biomarkers in question.
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