Schumacker PT. Hypoxia-inducible factor-1 (HIF-1). Crit Care Med 2005;33(12 Suppl):S423–S425. DOI: 10.1097/01.ccm.0000191716.38566.e0
Martin DS, Grocott MP. Oxygen therapy in critical illness: precise control of arterial oxygenation and permissive hypoxemia. Crit Care Med 2013;41(2):423–432.. DOI: 10.1097/CCM.0b013e31826a44f6
MacIntyre NR. Tissue hypoxia: implications for the respiratory clinician. Respir Care 2014;59(10):1590–1596. DOI: 10.4187/respcare.03357
Zhu H, Traore K, Santo A, et al. Oxygen and oxygen toxicity: the birth of concepts. React Oxyg Species (Apex) 2016;1(1):1–8. DOI: 10.20455/ros.2016.801
Girardis M, Busani S, Damiani E, et al. Effect of conservative vs conventional oxygen therapy on mortality among patients in an intensive care unit: the oxygen-icu randomized clinical trial. JAMA 2016;316(15):1583–1589. DOI: 10.1001/jama.2016.11993
Asfar P, Schortgen F, Boisramé-Helms J, et al. Hyperoxia and hypertonic saline in patients with septic shock (HYPERS2S): a two-by-two factorial, multicentre, randomized, clinical trial. Lancet Respir Med 2017;5(3):180–190. Lancet Respir Med 2017;5(8):e28. DOI: 10.1016/S2213-2600(17)30046-2
Chu DK, Kim LH, Young PJ, et al. Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis. Lancet 2018;391(10131):1693–1705. DOI: 10.1016/S0140-6736(18)30479-3
Helmerhorst HJ, Roos-Blom MJ, van Westerloo DJ, et al. Association between arterial hyperoxia and outcome in subsets of critical illness: a systematic review, meta-analysis, and meta-regression of cohort studies. Crit Care Med 2015;43(7):1508–1519. DOI: 10.1097/CCM.0000000000000998
Angus DC. Oxygen therapy for the critically ill. N Engl J Med 2020;382(11):1054–1056. DOI: 10.1056/NEJMe2000800
Farquhar H, Weatherall M, Wijesinghe M, et al. Systematic review of studies of the effect of hyperoxia on coronary blood flow. Am Heart J 2009;158(3):371–377. DOI: 10.1016/j.ahj.2009.05.037
Barrot L, Asfar P, Mauny F, et al. Liberal or conservative oxygen therapy for acute respiratory distress syndrome. N Engl J Med 2020;382(11):999–1008. DOI: 10.1056/NEJMoa1916431
Schjørring OL, Klitgaard TL, Perner A, et al. Lower or higher oxygenation targets for acute hypoxemic respiratory failure. N Engl J Med 2021;384(14):1301–1311. DOI: 10.1056/NEJMoa2032510
The ICU-ROX investigators and the Australian and New Zealand intensive care society clinical trials group, Mackle D, Bellomo R, et al. Conservative oxygen therapy during mechanical ventilation in the ICU. N Engl J Med 2020;382(11):989–998. DOI: 10.1056/NEJMoa1903297
Cumpstey AF, Oldman AH, Martin DS, et al. Oxygen targets during mechanical ventilation in the ICU: a systematic review and meta-analysis. Crit Care Explor 2022;4(4):e0652. DOI: 10.1097/CCE.0000000000000652
He HW, Liu DW, Long Y, et al. High central venous-to-arterial CO2 difference/arterial-central venous O2 difference ratio is associated with poor lactate clearance in septic patients after resuscitation. J Crit Care 2016;31(1):76–81. DOI: 10.1016/j.jcrc.2015.10.017